CIA Agent Jack Ryan is appointed acting CIA Deputy Director of Intelligence when his mentor, Admiral James Greer becomes gravely ill. His first assignment is to investigate the murder of one of the president's friends, a prominent U.S. businessman with secret ties to Colombian drug cartels. Caught in the crossfire, Ryan takes matters into his own hands.

CIA deputy intelligence director, Jack Ryan, finds recovering laundered drug money from the Colombian cartel isn't as dangerous as the power games in the nation's capitol.

Maria, a poor Columbian teenager, is desperate to leave a soul-crushing job. She accepts an offer to transport packets of heroin - which she swallows - to the United States. The ruthless world of drug trafficking proves to be more than she bargained for.

Now that the bloody hunt for Pablo Escobar has ended, the DEA turns its attention to the richest drug trafficking organization in the world: the Cali cartel. Led by four powerful godfathers, this cartel operates much differently than Escobar's, preferring to bribe government officials and keep its violent actions out of the headlines.